What Causes Elevated High Creatinine Levels

Creatinine is a waste metabolite produced by muscles after they have finished contracting. It is introduced into the blood and excreted into the urine by the kidneys. Elevated creatininelevels generally indicate a decline in kidney function. Impaired kidney function can happen gradually without a person being aware of it. A routine blood test showing an increased level ofcreatinine is often the first indication of kidney disease.
As kidneys are responsible for maintaining the normal range of blood creatinine, creatinine level is found to be the reliable indicator of kidney function. Elevated levels of blood creatinine indicate that there is poor clearance of creatinine by the kidneys. Abnormally high level of blood creatinine can be the indicator of possible failure of kidneys. During routine and standard blood tests, the amount of creatinine in blood is therefore checked. Urine creatinine levels also help access kidney function. The exact amount of creatinine clearance (CrCl) can be the precise measure to judge whether the kidneys are functioning smoothly or not. Estimation of glomerular filtration rate (GFR) helps evaluate kidney function.
Normal Blood Creatinine Levels
In adult men: approximately 0.6 to 1.2 mg/dl ( milligrams/deciliter)
In adult women: approximately 0.5 to 1.1 mg/dl
In a person with only one kidney: approximately 1.8 to 1.9
Infants: approximately 0.2 to 1.2 mg/dl depending upon their muscle development
Children: approximately 0.3 to 0.7 mg/dl depending upon their muscle development.
Teenagers: approximately 0.5 to 1.0 mg/dl depending upon their muscle development
High blood creatinine levels like 2.0 or more in infants and 10.0 or more in adults suggest severe kidney impairment. These patients need to undergo 'dialysis' which facilitates removal of wastes from the blood. But what are the conditions that lead to kidney dysfunction? Here is an overview of the causes of kidney dysfunction.
High Blood Pressure: Persistent high blood pressure or hypertension is the common cause of kidney problems.
Diabetes: Diabetes, over the years, affects the function of the kidneys seriously. It eventually can raise blood creatinine.
Side Effect of Medicines: Certain drugs are responsible for high amount of creatinine in blood.
Consumption of Meat: Consumption of large amount of dietary meat can lead to excess creatinine in blood.
Urinary Tract Obstruction: If formation of kidney stones leads to an obstruction in the urinary tract or if any other condition results in urinary tract obstruction, then blood creatinine levels can rise.
Dehydration: Dehydration can lead to high blood creatinine.
Excessive Blood Loss: Excessive blood loss that can cause a shock, may lead to dysfunction of kidneys.
Gout: Gout, a type of arthritis, can lead to damaged kidneys.
Muscle Conditions: Rhabdomyolysis, gigantism, muscular dystrophy, myasthenia gravis etc. can damage the kidneys.
Kidney Infection: Kidney infection can increase the amount of creatinine in blood.